Plant Transcription Factor Database
Previous version: v3.0
Selaginella moellendorffii
bZIP Family
Species TF ID Description
125734bZIP family protein
135978bZIP family protein
17886bZIP family protein
231160bZIP family protein
231344bZIP family protein
266892bZIP family protein
270282bZIP family protein
34663bZIP family protein
38594bZIP family protein
39427bZIP family protein
402651bZIP family protein
404596bZIP family protein
409920bZIP family protein
413715bZIP family protein
414340bZIP family protein
439314bZIP family protein
443825bZIP family protein
444176bZIP family protein
444199bZIP family protein
67189bZIP family protein
73196bZIP family protein
73198bZIP family protein
77868bZIP family protein
91900bZIP family protein
99404bZIP family protein
bZIP Family Introduction

The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.

Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Jakoby M, Weisshaar B, Droge-Laser W, Vicente-Carbajosa J, Tiedemann J, Kroj T, Parcy F
bZIP transcription factors in Arabidopsis.
Trends Plant Sci, 2002. 7(3): p. 106-11.
PMID: 11906833